Perskindol
Pine Needle Oil

Pine Needle Oil

  • Obtained from Pinus sylvestris leaves, twigs and branches
  • α-Pinene is one of the major constituents (7.0 -16.1 %) of needle essential oils of Pinus sylvestris8

Selected Properties

  • Anti-inflammatory
  • Antiseptic
  • Rubefascient
  • Contra-indicated in case of known allergies or hypersensitivity to pine oil

Mechanism of Action

Anti-inflammatory effect9

  • Most likely due to a reduction in the release of nitric oxide (NO, nitric acid)
  • α-Pinene induces suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages

Analgesia10

  • α-Pinene inhibits COX-2 overexpression in mice hind-paw model
  • Activation of endogenous opioid-dependent analgesic pathways

References

  1. A. JUDZENTIENE, E. KUPCINSKIENE, CHEMICAL COMPOSITION ON ESSENTIAL OILS FROM NEEDLES OF PINUS SYLVESTRIS L. GROWN IN NORTHERN LITHUANIA. JOURNAL OF ESSENTIAL OIL RESEARCH 20, 26-29 (2008).
  2. E. VIGO, A. CEPEDA, O. GUALILLO, R. PEREZ-FERNANDEZ, IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF PINUS SYLVESTRIS AND PLANTAGO LANCEOLATA EXTRACTS: EFFECT ON INDUCIBLE NOS, COX-1, COX-2 AND THEIR PRODUCTS IN J774A.1 MURINE MACROPHAGES. J PHARM PHARMACOL 57, 383-391 (2005).
  3. X.-J. LI, Y.-J. YANG, Y.-S. LI, W. K. ZHANG, H.-B. TANG, ?-PINENE, LINALOOL, AND 1-OCTANOL CONTRIBUTE TO THE TOPICAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF FRANKINCENSE BY INHIBITING COX-2. JOURNAL OF ETHNOPHARMACOLOGY 179, 22-26 (2016).