Perskindol
Orange Peel Oil

Orange Peel Oil

  • Obtained from Citrus limon skins
  • Limonene 73.9% -97 % is the major chemical compound39,40

Selected Properties

  • Anti-inflammatory
  • Analgesic
  • Reduces anxiety

Mechanism of Action

Anti-inflammatory effect34

  • Orange oil decreases inflammation by strongly inhibiting the 5-lipoxygenase activity

Analgesia41

  • R-(+)-limonene presents antinociceptive activity and probably this action can be related with peripheral analgesia (but not with the stimulation of opioids receptors)

Reduction of anxiety and depression42

  • Reduction of cortisol level and pulse rate in children

References

  1. S. M. NJOROGE, N. T. L. PHI, M. SAWAMURA, CHEMICAL COMPOSITION OF PEEL ESSENTIAL OILS OF SWEET ORANGES (CITRUS SINENSIS) FROM UGANDA AND RWANDA. JOURNAL OF ESSENTIAL OIL BEARING PLANTS 12, 26-33 (2009).
  2. A. Geraci, V. Di Stefano, E. Di Martino, D. Schillaci, R. Schicchi, Essential oil components of orange peels and antimicrobial activity. Natural Product Research 31, 653-659 (2017).
  3. J. F. do Amaral et al., Antinociceptive Effect of the Monoterpene R-(+)-Limonene in Mice. Biological and Pharmaceutical Bulletin 30, 1217-1220 (2007).
  4. M. Jafarzadeh, S. Arman, F. F. Pour, Effect of aromatherapy with orange essential oil on salivary cortisol and pulse rate in children during dental treatment: A randomized controlled clinical trial. Advanced Biomedical Research 2, 10 (2013).